Both strikers have scored multiple goals over the weekend, with Borussia Dortmund’s Erling Holland leading the way.
Star forwards Harry Kane and Robert Lewandowski have been named in the FIFA 21 Ultimate Team of the Week.
Cain beat Manchester United 6-1 over the weekend at Tottenham, with Bayern’s Lewandowski scoring all four of his goals in a 4-3 victory over Hertha Berlin.
The pair’s star forwards are at the top of the table after Borussia Dortmund ‘s 4-0 win over Freiburg.
Jack Greelish scored a pair of goals in Aston Villa’s 7-2 win over Liverpool. Substitutes include Olly Watkins, who scored a hat-trick.
Alan Saint-Maximine is a Premier League player. Everton’s James Rodriguez has also been named in the starting XI.
Real Madrid goalkeeper Thibaut Courtois is anchored in the backline as they continue their strong start to the season by beating Levante 2-0 for the Blancos.
On defense, Chelsea’s Ben Chilwell and AC Milan’s Theo Hernandez have a pair of left backs, while RB Leipzig center back Marcel Hustenberg surrounds the back line.
Real Betis veteran Joaquin, Portugal and Lille player Renato Sanchez also have a place in midfield.
FUT team of the week
GK: Tibet Courtois (Real Madrid) – 90 OVR
CB: Marcel Houstonberg (RB Leipzig) – 84 OVR
LB: Ben Chillwell (Chelsea) – 84 OVR
LB: Theo Hernandez (AC Milan) – 83 OVR
LM: Alan Saint-Maximine (Newcastle United) – 83 OVR
RM: Joaquin (Real Betis) – 83 OVR
LM: Jack Greelish (Aston Villa) – 83 OVR
CM: Renato Sanchez (Lille) – 82 OVR
ST: Robert Lewandowski (Bayern Munich) – 92 OVR
ST: Harry Kane (Tottenham Hotspur) – 89 OVR
ST: Earling Holland (Borussia Dortmund) – 86 OVR
GK: Rafael Djikovic (Augsburg) – 81 OVR
CB: Jose Luis Palomino (Atlanta) – 81 OVR
LM: Davidson (Allianzpor) – 81 OVR
LM: Mislav Orsik (Dinamo Zagreb) – 81 OVR
RM: James Rodriguez (Everton) – 84 OVR
ST: Angel Rodriguez (Getafe) – 82 OVR
ST: Ollie Watkins (Aston Villa) – 81 OVR
LM: Circan Sarrer (Turkuku Manchen) – 74 OVR
CM: Alexander Ring (New York City FC) – 80 OVR
RM: Marcus Harness (Portsmouth) – 75 OVR
RM: Danny Grant (Bohemian) – 70 OVR
ST: Ibrahim Neon (Mets) – 78 OVR
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