Rose Byrne returns to the Ireland squad to face England at Twickenham in the Autumn Nations Cup on Saturday. (Live at 3pm, RTÉ2).
The Leinster out-half is in the place of captain Johnny Sexton, who suffered a wrist injury in last week’s win over Wales.
This is the 25 – year – old’s ninth cap and second opener, having started 57-15 with England in London before last year’s World Cup.
“He deserves a chance,” said head coach Andy Farrell.
“He’s just like everyone else, how do you find out how they cope with great games and great opportunities?
“Ross has been involved in some great games for Leinster, and this is an opportunity to go to Twickenham and be part of a great team performance.
“I have no worries [about how he’ll deal with England out-half Owen Farrell].
“He’s going to play his own game. Everyone has a different character. On the weekend, Rose will be his own. The way he wants to play is very calm and serene.
Keith Earls, Bundy Aki and CJ Standard also return to the team.
Influencing Farrell in this first full cap at Aviva, Jamison Gibson-Park retained his place in the scrum-half, meaning veteran Conor Murray starts on the bench for the second consecutive Test.
“It’s a great game for us to get to know the group that needs to give people a chance on the big stage,” Farrell added.
Billy Burns, who replaced Sexton last Friday before returning for a head injury assessment, returned to the bench with Jacob Stokedale after recovering from a calf injury.
Ian Henderson, a member of Stoke Dale’s Ulster Club, also stepped down last week but found a place in the squad.
“Hugo deserves another start,” Farrell said when asked about the selection of Stoke Dale on the bench. “This is the first time we’ve started at Twickenham, so we’re excited about it. We’ll know more about him in that position. He did very well in the final.
“Jacob missed a few training sessions. I’m sure he will succeed when he’s ready to go.”
Connaught Center Aki Slots for Robbie Henshaw, who had trouble adapting, with Chris Farrell in the middle.
Hugo Keenan Earls on the right wing and James Low on the left remain full back.
Also in the front row are Cian Healy, Ronan Keller and Andrew Porter. James Ryan will captain the second tier company along with Quinn Rooks.
Standard Blindside starts at the flanker, Peter O’Malley switches over, and Callen Doris keeps at 8.
Substitute hookers include Rob Herring, Ed Byrne, Finley Bealeham and Will Connors.
England start the Autumn Nations Cup with a 40-0 win over Georgia. George Ford has been added to the 25-man squad ahead of Thursday’s team announcement.
Ireland: Hugo Keenan, Keith Earls, Chris Farrell, Bundy Aki, James Lowe, Ross Byrne, Jamieson Gibson-Park; Cian Healy, Ronan Keller, Andrew Porter, Quinn Rooks, James Ryan (capt), CJ Standard, Peter O’Malley, Callen Doris.
Replacement: Rob Herring, Ed Byrne, Finlay Billham, Ian Henderson, Will Connors, Conor Murray, Billy Burns, Jacob Stockdale.
Follow England v Ireland this Saturday via our live blog on RT Saturday.ie / sport and the RTÉ News app, watch live on RTÉ One from 2pm on Saturday, or listen to live updates on RTÉ Radio 1’s Saturday Sport.